The bioactive sphingolipid S1P is present in bloodplasma, bound to carrier proteins, and is involved in many physiological processes, including angiogenesis, inflammatory responses and vascular stabilization. S1P can bind to several G-protein-coupled receptors (GPCRs) activating a number of different signalling …

S1P-mediated G-protein and RhoGTPase signaling to control endothelial barrier function Read more »

The performance of Förster Resonance Energy Transfer (FRET) biosensors depends on brightness and photostability, which are dependent on the characteristics of the fluorescent proteins that are employed. Yellow fluorescent protein (YFP) is often used as an acceptor but YFP is …

Research highlight: Spectrally diverse FRET acceptors for mTurquoise2 Read more »

Researchers succeeded for the first time in mapping protein-protein interactions in living developing plant roots. The findings of the international team of the department of Plant Developmental Biology at Wageningen University and Research, the section of Molecular Cytology at the …

Research highlight: Shedding light on protein interaction networks Read more »