Research highlight
Glowing Bacteria Micropia
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Elucidating S1P-mediated signaling with biosensors
S1P binds to several G-protein-coupled receptors (GPCRs) activating a number of different signalling networks. This study explores these pathways by using a set of FRET-based biosensors for different RhoGTPases (Rac1, RhoA/B/C, Cdc42) as well as for heterotrimeric G-proteins in a series of live-cell imaging experiments in primary human endothelial cells.
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Bright red fluorescent protein created
After years of trying, biologists have succeeded in creating an extremely bright red fluorescent protein in the lab. This is good news for researchers, including cancer and stem cell researchers, who use fluorescent proteins to track essential cellular processes.
The researchers at the University of Amsterdam & Institut de Biologie structurale and the European Synchrotron in Grenoble describe their approach in the latest edition of the journal Nature Methods.
Nature Methods.
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