Month: November 2017

S1P-mediated G-protein and RhoGTPase signaling to control endothelial barrier function

The bioactive sphingolipid S1P is present in bloodplasma, bound to carrier proteins, and is involved in many physiological processes, including angiogenesis, inflammatory responses and vascular stabilization. S1P can bind to several G-protein-coupled receptors (GPCRs) activating a number of different signalling